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 Printable version |
Therapeutical indications of the intravenous immunoglobulin (except in autoimmune thrombopenic purpura) |
Hématologie. Volume 11, Number 3, 209-16, Mai-Juin 2005, Revue
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 Résumé
Article gratuit
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Author(s) : Luc Mouthon, Alice Berezné, Véronique Le-Guern, Loïc Guillevin |
Summary : Intravenous immunoglobulin (IVIg) are therapeutic preparations of normal human IgG that are obtained from pools of healthy blood donors. IVIg can be used at low dose in the substitive therapy of patients with primary or secondary immune deficiencies or at high dose as an immunomodulatory agent in a large number of autoimmune and/or systemic inflammatory diseases, particularly in hematologic or neurologic diseases. Tolerance to IVIg is excellent in most of the cases and the risk of transmission of an infectious agent is only theoretical. Mechanisms of action of IVIg are multiple and intricated. The development of new therapeutic trials in association with analyses of mechanisms of action should help to define new indication of IVIg therapy. |
Keywords : intravenous immunoglobulin, IgG, autoimmune disease, humoral immune deficiencies |
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