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 Printable version |
Role of the hippocampus-entorhinal cortex loop in the temporal lobe epilepsy |
Epilepsies. Volume 19, Number 1, 11-22, Janvier, Février, Mars 2007, Article original
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 Résumé
Article gratuit
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Author(s) : Etienne Labyt, Fabrice Wendling |
Summary : Mechanisms involved in the generation and the propagation of epileptic activities within the Hippocampus – Entorhinal cortex (EC) loop were studied with a computational model based on cellular organization and connections data derived from the literature. Model parameters, reflecting synaptic interactions within and between structures, were tuned according to quantitative comparison between human intracerebral EEG recordings from Hippocampus and EC and corresponding simulated signals. Results show that the model generates very realistic signals regarding temporal dynamics and spectral features. In the model, epileptic activities were obtained in Hippocampus and EC when parameters were set to reproduce the neuronal loss within dentate gyrus (DG) and mossy fibers sprouting. Generation of epileptic activities was essentially explained in the model by time evolution of GABAergic inhibition mediated by GABAa slow, GABAa fast and GABAb receptors. When normal conditions within DG were reproduced, epileptic activities were mainly restricted to EC, supporting the hypothesis of « filter » role for DG. These findings are discussed with respect to experimental data. |
Keywords : hipocampus-entorhinal cortex loop, temporal lobe epylepsy, gyrus dentatus, GABAergic inhibition |
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