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 Printable version |
Cerebral malaria and epilepsy: synthesis of 2 epidemiological studies in sub-saharan Africa |
Epilepsies. Volume 18, Number 4, 193-7, Octobre, Novembre, Décembre 2006, Article original
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 Résumé
Article gratuit
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Author(s) : EB Ngoungou, O Dulac, M Druet-Cabanac, M Kombila, O Doumbo, PM Preux |
Summary : Cerebral Malaria (CM) is a potential cause of epilepsy occurrence in tropical area. Two recent complementary epidemiological approaches were performed in sub-Saharan Africa, in Mali and in Gabon and aimed at quantifying the relationship between these two affections. The first one, an exposed/non-exposed study, was performed in Malian children followed-up after clinical malaria. Among them, 101 with a CM history were compared with 222 with non cerebral malaria (NCM) history. The risk of developing epilepsy was higher after CM than after NCM : aRR \= 14.3 [95% CI : 1.6-132.0] \; p \= 0.01. The second approach, a matched case-control study, was performed in a Gabonese population aged of 6 months to 25 years, at 3 different hospitals in Libreville, with 15 years retrospectively. 296 people with epilepsy were compared with 296 people not suffering from epilepsy. The risk of developing epilepsy was higher after a CM in cases than in controls : aOR \= 3.9 [95% CI : 1.7-8.9], p <\; 0.001. This work confirms the role of CM in the occurrence of sequelar epilepsy. However, the implication of seizures during CM and physiopathological mechanisms remains obscure and needs to be confirmed. |
Keywords : cerebral malaria, sequelar epilepsy, epidemiological studies, Mali, Gabon |
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