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Mirth and laughter elicited during brain stimulation


Epileptic Disorders. Volume 13, Number 4, 435-40, December 2011, Clinical commentaries

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Author(s) : Guadalupe Fernández-Baca Vaca, Hans O Lüders, Maysaa Merhi Basha, Jonathan P Miller

Summary : There are few reports of laughter and/or mirth evoked by electrical stimulation of the brain. In this study, we present a patient with intractable epilepsy in whom mirth and laughter was consistently produced during stimulation of the left inferior frontal gyrus (opercular part) using stereotactically placed depth electrodes. A review of the literature shows that cortical sites that produce mirth when stimulated are located in the dominant hemisphere close to language areas or cortical negative motor areas.

Keywords : brain stimulation, cortical mapping, mirth, laughter, language areas, negative motor areas, gelastic seizures

 

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