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MRI-negative frontal lobe epilepsy with ipsilateral akinesia and reflex activation


Epileptic Disorders. Volume 10, Number 4, 349-55, December 2008, Anatomo-electro-clinical correlations with video sequences

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Author(s) : Stephen Malone, Ian Miller, Prasanna Jakayar, Trevor Resnick, Sanjiv Bhatia, Michael Duchowny

Summary : [Case records of Epileptic Disorders. Anatomo-electro-clinical correlations. Case 04-2008] The pre-operative assessment and surgical management of children and young adults with MRI-negative, frontal lobe epilepsy is often challenging owing to the semiologic expression being unusual or non-lateralizing. Localization based on functional tests may be non-convergent, further compounding the difficulty of surgical planning. We describe a patient with seizures presenting with early, subjective akinesia of the dominant hand that were at times triggered by repetitive motor tasks. Subdural EEG monitoring revealed seizure-origin in the ipsilateral dorsolateral frontal lobe. After resective surgery the patient has had a seizure free period of 9 months, and is free of deficits. This is the first report of frontal lobe seizure semiology consisting of ipsilateral ictal akinesia. [Published with video sequences]

Keywords : childhood epilepsy, frontal lobe epilepsy, epilepsy surgery, presurgical assessment

 

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