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 Printable version |
Calcipotriol plus betamethasone dipropionate gel compared with its active components in the same vehicle and the vehicle alone in the treatment of psoriasis vulgaris: a randomised, parallel group, double-blind, exploratory study |
European Journal of Dermatology. Volume 20, Number 4, 465-71, July-August 2010, Therapy
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 Free Article
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Author(s) : Colin Fleming, Cecilia Ganslandt, Lyn Guenther, Anders Johannesson, Colin Buckley, Jan C Simon, Helen Stegmann, Lotte Vestergaard Tingleff |
Summary : A two-compound ointment containing calcipotriol plus betamethasone dipropionate is an effective treatment for psoriasis vulgaris. The same active ingredients have now been combined in a gel formulation. Our objective was to compare the efficacy and safety of once daily treatment of the two-compound gel with the single components in the same gel vehicle and the gel vehicle alone, in patients with psoriasis vulgaris on the trunk and/or limbs. 364 patients received once daily treatment for up to 8 weeks with either the two-compound gel, the single components in the gel vehicle or the gel vehicle alone. The percentage of patients whose disease was clear or very mild and who had at least a two-step improvement in the Investigator's Global Assessment of disease severity at week 8, was significantly higher with calcipotriol plus betamethasone dipropionate (27.2%) than with betamethasone dipropionate (16.9%, p \= 0.027), calcipotriol (11.4%, p \= 0.006) or gel vehicle (0.0%, p <\; 0.001). This exploratory study showed that the two-compound gel was safe and more efficacious than its individual ingredients in the treatment of psoriasis vulgaris. |
Keywords : betamethasone dipropionate, calcipotriol, combination therapy, psoriasis vulgaris |
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