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 Printable version |
Depression in hospitalized patients with malignant melanoma treated with interferon-alpha-2b: primary to induced disorders |
European Journal of Dermatology. Volume 19, Number 6, 611-5, November-December 2009, Clinical report
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 Free Article
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Author(s) : Ricard Navinés, Esther Gómez-Gil, Susana Puig, Inmaculada Baeza, Joan De Pablo, Rocío Martín-Santos |
Summary : Our objective was to study the clinical and management differences between primary and interferon (IFN)-induced depressive disorders in malignant melanoma patients visited by the consultation-liaison team during a two year period. This was a prospective study of 31 patients with malignant melanoma treated with IFN-alpha in a general teaching hospital. Clinical, psychiatric variables and DSM-IV-TR diagnosis were analyzed. The Clinical Global Impression Severity (CGI-S) and Improvement (CGI-I) of illness scales were administered at the time of consultation and at the end of hospitalization. The main diagnoses were depressive adjustment disorders in 14 patients (45.16%) followed by interferon-induced depressive disorders in 6 (19.36%). In patients with adjustment disorders, melanoma stage was significantly more advanced than in those with interferon-induced depressive disorder (p \= 0.019). The latter scored higher in the CGI-S scale (p \= 0.044) and in the CGI-I scale (p \= 0.029). The interferon-induced depressive disorders, except one who required a reduction of IFN-alpha-2b dose, were successfully treated with antidepressant drugs. Clinical management and antidepressant treatment allowed the continuation of interferon therapy in malignant melanoma patients. Interferon-induced depression occurred in a few patients, which in turn were the most severe. Adjustment depressive disorder was the most common psychiatric diagnosis. |
Keywords : malignant melanoma, interferon-alpha, depression, adjustment disorder, interferon-induced depressive disorder |
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