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 Printable version |
Association between IL4 (–590), ACE (I)/(D), CCR5 (Δ32), CTLA4 (+49) and IL1-RN (VNTR in intron 2) gene polymorphisms and vitiligo |
European Journal of Dermatology. Volume 19, Number 2, 126-8, March-April 2009, Investigative report
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 Free Article
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Author(s) : Sacide Pehlivan, Ferda Ozkinay, Sibel Alper, Huseyin Onay, Eda Yuksel, Mustafa Pehlivan, Cihangir Ozkinay |
Summary : Vitiligo is a common skin disorder characterized by patterned depigmentation, because of a decrease of melanin pigment resulting from apparent melanocyte loss. The aim of this study was to investigate interleukin 4 (IL4), Angiotensin Converting Enzyme (ACE), C-C Chemocine Receptor 5 (CCR5), Cytotoxic T Lymphocyte-associated Antigen Receptor 4 (CTLA4) and Interleukin 1 Receptor Antagonist (IL1-RN) gene polymorphisms in 48 Turkish vitiligo patients and 50 healthy controls. Polymorphisms for the genes ACE insertion(I)/deletion(D), CCR5 (Δ32), IL1-RN (VNTR in intron 2) were detected by PCR methods. IL4 (-590) and CTLA4 (+49) gene polymorphisms were typed using PCR-RFLP methods. No significant differences in either the genotype distribution or allele frequencies of IL4, CCR5 and ACE gene polymorphisms were observed. GG genotype and G allele in CTLA4 genes were found to be significantly higher in vitiligo patients compared to the controls. (0.002, 0.000). CTLA4 (AA) and IL1-RN (1/5) genotypes and 5 allele frequency in the IL1-RN gene were found to be significantly lower in vitiligo patients compared to healthy controls (p: 0.014, 0.015, 0.016, respectively). As a conclusion, CTLA4 and IL1-RN genes might play roles in the genetic etiology of vitiligo. |
Keywords : ACE, CCR5, CTLA4, IL1-RN, IL4, vitiligo, polymorphisms |
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