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Incidental cases of subacute cutaneous lupus erythematosus in association with malignancy


European Journal of Dermatology. Volume 18, Number 6, 700-4, Novembre-Décembre 2008, Clinical report

Free Article  

Author(s) : Regina Renner, Michael Sticherling

Summary : Malignancy and chronic inflammatory diseases seem to be associated to one another. Here we review the literature regarding subacute cutaneous lupus erythematosus (SCLE) and concomitant neoplasia on the basis of 3 short case reports of patients with SCLE who developed breast cancer and lung cancer respectively after long-term disease activity and immunosuppressive therapy. Possible hypotheses for this co-incidence could be: i) malignancy as a consequence of chronic inflammation, ii) malignancy as a consequence of immunosuppressive therapy, iii) paraneoplastic disease, iv) local malignancy following a persisting proliferative or reparative process or v) only coincidental occurrence.

Keywords : lupus erythematosus, malignancy, breast cancer, lung cancer

 

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