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 Printable version |
Progression of hair loss in men with androgenetic alopecia (male pattern hair loss): long-term (5-year) controlled observational data in placebo-treated patients |
European Journal of Dermatology. Volume 18, Number 4, 407-11, July-August 2008, Investigative report
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 Free Article
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Author(s) : Keith D Kaufman, Cynthia J Girman, Elizabeth M Round, Amy O Johnson-Levonas, Arvind K Shah, Jennifer Rotonda |
Summary : Relatively little is known about the progression of androgenetic alopecia (AGA\; male pattern hair loss) in untreated men. We evaluated the long-term (5-year) progression of AGA in men treated with placebo in a controlled clinical trial setting. We analyzed pooled data over 5 years from two replicate studies with finasteride 1 mg/day in men with predominantly vertex-pattern AGA. Each study consisted of an initial 1-year, randomized, double-blind, placebo-controlled base study and four consecutive, 1-year, double-blind, placebo-controlled extension studies. Change over time in scalp hair growth was evaluated by four predefined endpoints: scalp hair counts\; assessment of standardized clinical photographs by an expert panel\; investigator clinical assessment\; and patient self-assessment. All four predefined endpoints demonstrated progressive scalp hair loss in men receiving placebo over the 5-year study period, with a loss of 239 hairs from baseline (26.3% decline in hair density) measured in the target area at 5 years (p <\; 0.001 vs. baseline). Similarly, visible progression of scalp hair loss was demonstrated by global photographic assessment, with 75% of placebo patients rated as worsened from baseline at 5 years. We found that scalp hair loss continued in a progressive manner over a 5-year period in placebo-treated men with AGA. |
Keywords : androgenetic alopecia, finasteride, 5α-reductase inhibitor, global photographic assessment, patient self-assessment |
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