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 Printable version |
Primary cutaneous aggressive epidermotropic CD8
+ T-cell lymphoma with a CD15
+CD30
– phenotype |
European Journal of Dermatology. Volume 17, Number 5, 441-2, September-October 2007, Clinical report
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 Free Article
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Author(s) : Naho Yoshizawa, Hiroaki Yagi, Takahiro Horibe, Masahiro Takigawa, Makoto Sugiura |
Summary : Primary cutaneous aggressive epidermotropic CD8
+ T-cell lymphoma (CD8
+TCL) is an extremely rare entity with distinct clinicopathological features. While the CD15 antigen is typically associated with classic Hodgkin’s lymphoma, aggressive peripheral T-cell lymphomas, including advanced stage cutaneous T-cell lymphomas, rarely express this molecule. We report a case of primary cutaneous aggressive epidermotropic CD8
+TCL, in which lymphoma cells are CD15
+CD30
– with a medium-to-large pleomorphic phenotype. Although the functional characteristics of CD15 expression in the cutaneous lymphomas are not fully understood, the poor prognosis of primary cutaneous aggressive epidermotropic CD8
+TCL might be associated with the presence of this molecule in our case. |
Keywords : CD8
+TCL, CD8
+ T-cell lymphoma, CTCL, Cutaneous T-cell lymphoma, EBV, Epstein-Barr virus, MF, Mycosis fungoides, TCR, T-cell receptor |
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