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 Printable version |
Epstein-Barr virus-associated post-transplant lymphoproliferative disorder presenting with skin involvement after CD34-selected autologous peripheral blood stem cell transplantation |
European Journal of Dermatology. Volume 17, Number 3, 242-4, May-June 2007, Clinical report
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 Free Article
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Author(s) : Sanae Takahashi, Daisuke Watanabe, Kazuhisa Miura, Hiroaki Ozawa, Yasuhiko Tamada, Kazuo Hara, Yoshinari Matsumoto |
Summary : We report a case of Epstein-Barr virus (EBV)-associated post-transplant lymphoproliferative disorder (PTLD) after CD34-selected autologous peripheral blood stem cell transplantation (PBSCT). A 54-year-old woman with multiple myeloma underwent CD34-selected autologous PBSCT. The patient’s post-transplantation course was complicated by fever, pancytopenia and CMV antigenemia. On day 128 post PBSCT, a skin biopsy from an erythematous nodule on the right anterior chest revealed a deep dermal infiltrate of atypical CD20 and CD79a-positive B-cells with centroblastic large cell morphology. EBV reactivation was confirmed by immnohistochemistry, in situ hybridization and Southern blot analysis. These findings represent monomorphic PTLD having pathological features of a large cell-type B-cell lymphoma. Bone marrow aspiration also demonstrated hemophagocytic syndrome (HPS), accompanied with infiltration of EBV-positive B-cells. Despite treatment with rituximab and hydroxyurea, the patient died 155 days after transplantation. |
Keywords : Epstein-Barr virus, EBV, post-transplant lymphoproliferative disorder, PTLD, hemophagocytic syndrome, autologous peripheral blood stem cell transplantation |
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