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 Printable version |
Genital Paget’s disease in a man |
European Journal of Dermatology. Volume 16, Number 1, 75-8, January-February 2006, Clinical report
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 Free Article
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Author(s) : Walter Krause, Andreas Krisp, Stefan Hörster, Rolf Hoffmann |
Summary : Pagetoid cells are large intraepidermal cells which spread intraepidermally. We report a 67-year old Caucasian male, who presented for the first time in 1993 with a long-standing pruritic lesion at the scrotum. He was treated for several years by antiinflammatory ointments. Only in July 2003 was a biopsy taken for the first time. The histopathological evaluation revealed the diagnosis of an extrammamary Paget’s disease (EMPD). Pagetoid cells are large intraepidermal cells with a large nucleaus and ample cytoplasm. EMPD consists of primary malignant cells of epidermal origin, but in rare cases, pagetoid cells may also originate from carcinomas with epidermotropic growth. EMPD is a slowly progressing disease, but invading and metastasing tumors may also develop. Considering the good prognosis with long-term survival, nonsurgical modalities should be considered as primary treatment for noninvasive EMPD. |
Keywords : EMPD, Paget disease |
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