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 Printable version |
Microvessel density and HIF-1α expression correlate with malignant potential in fibrohistiocytic tumors |
European Journal of Dermatology. Volume 15, Number 6, 465-9, November-December 2005, Investigative report
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 Free Article
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Author(s) : Kaori Koga, Kazuki Nabeshima, Noriko Nishimura, Mikiko Shishime, Juichiro Nakayama, Hiroshi Iwasaki |
Summary : Angiogenesis is a central process in the growth of solid tumors. Hypoxia-inducible factor-1α (HIF-1α) is an oxygen-dependent transcriptional activator, which plays a crucial role in tumor angiogenesis. However, involvement of HIF-1α has never been studied in so-called fibrohistiocytic tumors, such as dermatofibroma (DF), dermatofibrosarcoma protuberans (DFSP) and malignant fibrous histiocytoma (MFH). We analyzed the extents of angiogenesis in relation to the expression levels of HIF-1α in 26 DF, 13 DFSP and 23 MFH cases. MFH showed significantly higher microvessel density (MVD) compared with DF and DFSP. Immunohistochemically, HIF-1α-positive cases constituted 31%, 15% and 98% of DF, DFSP and MFH, respectively, indicating significantly higher HIF-1α expression in MFH compared with DF and DFSP. Furthermore, MFH cases expressing high levels of HIF-1α showed significantly higher MVD than those with low levels of HIF-1α. Thus, higher levels of angiogenesis and HIF-1α expression are both closely associated with the malignant potential in so-called fibrohistiocytic tumors, and HIF-1α is possibly involved in angiogenesis in MFH. |
Keywords : angiogenesis, dermatofibroma, dermatofibrosarcoma protuberance, malignant fibrous histiocytoma, HIF-1α |
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