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 Printable version |
Recurrence rate of superficial basal cell carcinoma following successful treatment with imiquimod 5% cream: interim 2-year results from an ongoing 5-year follow-up study in Europe |
European Journal of Dermatology. Volume 15, Number 5, 374-81, September-October 2005, Therapy
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 Free Article
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Author(s) : Harald Gollnick, Carlos Guillén Barona, Ronald GJ Frank, Thomas Ruzicka, Mosaad Megahed, Veronica Tebbs, Mary Owens, Patti Stampone |
Summary : Imiquimod is an immune response modifier that acts through Toll-like receptor 7 to induce innate and cell-mediated immune responses. This ongoing phase III, open-label study conducted in Europe is evaluating the long-term (5 year) clinical efficacy and safety of imiquimod 5% cream applied once daily 5 times per week (5 ×/week) for 6 weeks for the treatment of superficial basal cell carcinoma (sBCC). A total of 182 subjects were enrolled. The initial sBCC clearance rate was 90% (12-week post treatment), whereas the proportion of subjects who were clinically clear at 2 years (current time point) was estimated to be 79.4%. Local skin/application site reactions were the most frequently reported safety findings. Initial efficacy rates of imiquimod applied 5 ×/week for 6 weeks demonstrate its clinical utility as an alternative approach to the treatment of sBCC. The recurrence rate seen to date supports ongoing follow up of subjects treated with imiquimod. |
Keywords : imiquimod, immune response modifier, long-term follow-up study, recurrence, superficial basal cell carcinoma |
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