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 Printable version |
Pathological score for the evaluation of allograft rejection in human hand (composite tissue) allotransplantation |
European Journal of Dermatology. Volume 15, Number 4, 235-8, July-August 2005, Investigative report
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 Free Article
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Author(s) : Jean Kanitakis, Palmina Petruzzo, Denis Jullien, Lionel Badet, Maria Clara Dezza, Alain Claudy, Marco Lanzetta, Nadey Hakim, Earl Owen, Jean-Michel Dubernard |
Summary : The experience obtained from the human hand allografts (HHA) performed to date suggests that the skin is a priviledged target of allograft rejection in this setting. The aim of this study was to establish a pathological score for assessing the severity of HHA rejection. The pathological slides of 89 skin biopsies obtained from the allografted limbs of six HHA recipients from day 0 to 5 years post-graft were retrospectively examined. According to the severity of the pathological changes observed, the following grades of rejection are proposed: 0: no rejection, I: mild rejection, II: moderate rejection, III: severe rejection, IV: very severe rejection. This grading system can be used as a basis for monitoring allograft rejection and for assessing the effects of the immunosuppressive treatment aiming at reversing HHA rejection\; it can also be used for monitoring rejection of other skin-containing CTA. |
Keywords : composite tissue allografts, human hand allografts, pathology, rejection |
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