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 Printable version |
Association between psoriasis vulgaris and MHC-DRB, -DQB genes as a contribution to disease diagnosis |
European Journal of Dermatology. Volume 15, Number 3, 159-63, May-June 2005, Investigative report
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 Free Article
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Author(s) : Claudia Bueno Cardoso, Ana Maria Uthida-Tanaka, Renata Ferreira Magalhães, Luiz Alberto Magna, Maria Helena Stangler Kraemer |
Summary : We analyzed 100 control individuals and 60 patients with psoriasis vulgaris from the population of Campinas, Brazil. Typification of class II HLA alleles (HLA-DRB1-5 and -DQB1) was carried out through the DNA/PCR/SSP at medium and high resolution. DNA was extracted through a salting-out procedure: 13 DRB1 alleles, 3 DRB3 alleles, 1 DRB4 allele, 2 DRB5 alleles, and 5 DQB1 alleles were identified at a medium resolution using the PCR/SSP, and 45 DRB1 alleles were identified at a high resolution in analyzed patients. Results showed associations with psoriasis vulgaris: positive associations HLA-DRB3*02 (p <\; 0.05, χ
2 \= 5.10, RR \= 2.14)\; HLA-DRB1*0102 alleles (p <\; 0.05, RR \= 5.44). Negative associations were found for HLA-DRB4*01 (χ
2 \= 3.23, RR \= 0.55) and HLA-DRB1*1302 alleles (p <\; 0.05, RR \= 0.23). The haplotypes revealed positive association for HLA-DRB1*0102/DQB1*05 (p <\; 0.05, RR \= 5.44) and HLA-DRB1*0701/DQB1*03 alleles (p <\; 0.02, RR \= 9.00). These findings suggest a possible association of the DRB1 allele with the group of patients showing an early onset of the illness, as well as an association with haplotypes HLA-DRB1*0102/DQB1*05 and HLA-DRB1*0701/DQB1*03. |
Keywords : psoriasis vulgaris, HLA-DRB, -DQB genes, MHC-association, triggering factors, Brazilian population |
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