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 Printable version |
Co-existence of pemphigus vulgaris and Hashimoto’s thyroiditis |
European Journal of Dermatology. Volume 15, Number 1, 40-2, January-February 2005, Clinical report
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 Free Article
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Author(s) : Yuko Iino, Hiroyuki Hara, Takane Suda, Tomoyoshi Okada, Shunichi Baba, Hiroyuki Suzuki |
Summary : We report a case of pemphigus vulgaris (PV) associated with Hashimoto’s thyroiditis. Direct immunofluorescent studies revealed intercellular deposits of IgG and C3. Both anti-desmoglein (Dsg) 1 and Dsg 3 antibodies were positive in the patient’s serum by enzyme-linked immunosorbent assays. HLA genotyping was performed from the patient’s peripheral blood leukocytes by polymerase chain reaction. HLA-A*02011, -A*2402101, -DQA1*0104, -DQB1*05031 and -DRB1*1405 alleles, which confer strong susceptibility to Japanese patients with PV, were found. HLA-DQA1*0303 which is strongly associated with Hashimoto’s thyroiditis in the Japanese population was also determined. |
Keywords : pemphigus vulgaris, Hashimoto’s thyroiditis, desmoglein (Dsg)1, Dsg3, HLA-DNA typing |
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