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 Printable version |
Efficacy and local safety of a calcipotriol/ betamethasone dipropionate ointment in elderly patients with psoriasis vulgaris |
European Journal of Dermatology. Volume 15, Number 1, 37-9, January-February 2005, Therapy
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 Free Article
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Author(s) : Richard Parslew, Jette Traulsen |
Summary : The proportion of elderly patients with psoriasis vulgaris is set to increase in the future due to an ageing population. This descriptive analysis assessed the efficacy and safety of a new ointment containing calcipotriol and betamethasone dipropionate (Daivobet
®/Dovobet
®) in a pooled analysis of patients aged 60 years and over. A total of 1534 patients, including 357 aged ≥ 60 years, with psoriasis vulgaris received the two-compound ointment once-daily in four randomised, double-blind, studies. After 4 weeks treatment the mean reduction in PASI was 67.8% in patients <\; 60 years compared with 72.6% in patients ≥ 60 years. “Controlled disease” (i.e. a global assessment of “absence of disease” or “very mild disease”), according to the investigators, was achieved by 52.1% of patients <\; 60 years and 58.2% of patients ≥ 60 years. Patients in both age groups reported a similar number of lesional/perilesional adverse drug reactions\; 6.4% in patients <\; 60 years vs 5.0% in patients ≥ 60 years. Thus, the new two-compound ointment is effective and well-tolerated in the treatment of psoriasis vulgaris, regardless of age group. |
Keywords : betamethasone dipropionate, calcipotriol, geriatric, psoriasis therapy |
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