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 Printable version |
Localised vulva Langerhans cell histiocytosis |
European Journal of Dermatology. Volume 14, Number 6, 412-4, November-December 2004, Clinical report
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 Free Article
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Author(s) : Hikaru ISHIGAKI, Naohito HATTA, Mizuki YAMADA, Hidemitsu ORITO, Kazuhiko TAKEHARA |
Summary : A cutaneous lesion as sole manifestation of adult Langerhans cell histiocytosis is rare. We report a 65-year old female who presented with vulvar ulcers. Histological examination of the ulcer showed diffuse proliferation of histiocytic cells with large bright cytoplasm that were positively stained for anti-S-100 protein and anti-CD1a antibodies by immunohistochemistry. Electron microscopy demonstrated Birbeck granules in the cytoplasm of the cells. Since there was no other organ involvement, the patient was treated by complete surgical excision without recurrence or other-organ involvement in the 1-year follow-up period. |
Keywords : Langerhans cell histiocytosis, ulcer, vulva |
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