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 Printable version |
Cutaneous ulcers with type I cryoglobulinemia treated with plasmapheresis |
European Journal of Dermatology. Volume 14, Number 3, 186-9, May - June 2004, Clinical report
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 Free Article
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Author(s) : A.T. VILA, M.A. BARNADAS, J. BALLARÍN, R. GARCÍA, C. JUAREZ, P. MADOZ, E. RAMILA, A. ALOMAR |
Summary : Severe necrotic cutaneous ulcers and kidney involvement secondary to type I cryoglobulinemia can be a therapeutic challenge. Plasmapheresis has been reported useful to treat autoimmune diseases such as thrombotic thrombocytopenic purpura, systemic lupus erythematosus, myasthenia gravis and Goodpasture’s syndrome. We report the case of a patient who presented necrotic lesions with kidney involvement due to type I cryoglobulinemia (Ig G κ) that evolved to a multiple myeloma. Treatment with high doses of corticosteroid plus cyclophosphamide did not control the disorder. Therapy with plasmapheresis produced a marked decrease in cryoglobulin levels and a subsequent relevant clinical improvement of cutaneous lesions and renal function. In cryoglobulinemia, plasmapheresis can be used as effective adjunt therapy to minimize cutaneous, renal and\\or neurologic involvement. |
Keywords : Cryoglobulinemia, plasmapheresis, leukocytoclastic vasculitis, renal failure |
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