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 Printable version |
Lack of association between Vitamin D receptor
FokI polymorphism and alopecia areata |
European Journal of Dermatology. Volume 14, Number 3, 156-8, May - June 2004, Investigative report
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 Free Article
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Author(s) : Ahmet AKAR, Funda Elif ORKUNOGLU, Metin OZATA, Ali SENGUL, Ali Riza GUR |
Summary : Vitamin D receptor (VDR) is expressed in the hair follicle and the lack of it leads to alopecia. In this study, we investigated whether there was a relationship between VDR
FokI gene polymorphism and alopecia areata (AA). This is the first study investigating the relationship between VDR gene polymorphism and AA. Twenty‐five patients with the extensive forms of AA (alopecia totalis\; AT, alopecia universalis\; AU and AT\\AU) and 27 healthy control subjects were genotyped. Their genotypes were determined by a polymerase chain reaction (PCR) and restriction fragment length polymorphism analysis. The genotypes were classified as
FF (absence of the
FokI site) and
ff (presence of the
FokI site). Allele frequencies for
F and
f alleles were 76.0% and 24.0% in the alopecic group and 72.2% and 27.7% in the control group (p > 0.05). The frequencies for the
FF,
Ff and
ff genotypes were 56.0%, 40.0% and 4.0% in the patient group, and 48.1%, 48.1% and 3.7% in the control group, respectively. No statistically significant differences were observed in the frequencies of the VDR
FokI genotype between the patient and the control groups. However, to conclude that there is no relationship between VDR gene polymorphism and AA, the VDR
FokI polymorphism should be further studied in other populations, larger groups, and the distribution of other VDR polymorphisms such as
BsmI,
Tru9I,
ApaI,
TaqI and
polyA. |
Keywords : alopecia areata, vitamin D receptor gene, VDR, FokI restriction polymorphism |
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