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 Printable version |
Long‐term efficacy and safety of topical tacrolimus in the management of ulcerative\erosive oral lichen planus |
European Journal of Dermatology. Volume 13, Number 5, 466-70, September 2003, Therapy
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 Free Article
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Author(s) : Tim A. HODGSON, Neeraj SAHNI, Fotini KALIAKATSOU, John AG BUCHANAN, Stephen R PORTER |
Summary : The long‐term safety and clinical benefit of topical tacrolimus for the management of erosive or ulcerative oral lichen planus has not been evaluated. 50 adults (39 female 11 male\; group median age 59, range 29‐88 years) with symptomatic, erosive or ulcerative lichen planus recalcitrant to topical corticosteroids applied 0.1% topical tacrolimus ointment twice daily to symptomatic mucosal lesions. Topical tacrolimus was applied for a median time of 19.8 months (range 2‐39 months) in this patient group. Fourteen percent of the patients had complete resolution of ulcers or erosions, 80% partial resolution and 6% reported no clinical benefit. The most common adverse effects were a burning sensation (16%) at the site of application and transient taste disturbance (8%). No significant, long‐standing changes in hepatic or renal biochemistry were observed. The mean tacrolimus level decreased with duration of therapy from 2.7 µg\\l (week 1) to 0.5 µg\\l (week 32). 0.1% topical tacrolimus is an effective means of controlling the symptoms and signs of erosive or ulcerative oral lichen planus and has no notable adverse effects over a mean duration of application of 19.8 months. |
Keywords : lichen planus, oral, tacrolimus, therapy |
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