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 Printable version |
Comparison of
99mTc‐MIBI scintigraphy and sentinel node biopsy in the detection of occult lymph node metastases from cutaneous melanoma |
European Journal of Dermatology. Volume 13, Number 5, 449-54, September 2003, Investigative report
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 Free Article
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Author(s) : Omar ALONSO, Miguel MARTÍNEZ, Lucía DELGADO, Graciela LAGO, Cecilia JURI, Alejandra Larre BORGES, María C. LOPES DE AMORIM, Daniela DE BONI, José ESPASANDÍN, Julio PRIARIO |
Summary :
99mTc‐MIBI scintigraphy has been proposed as a technique that can diagnose clinically undetectable melanoma metastases. The aim of the study was to compare the sensitivity of
99mTc‐MIBI with that of sentinel node biopsy (SNB) in the detection of nodal disease. Twenty‐eight patients with melanoma > 1.0 mm thick were enrolled. Patients underwent
99mTc‐MIBI scintigraphy and a preoperative lymphoscintigraphy followed by SNB. Sentinel nodes were identified in 27\\28 patients. Twelve patients had an involved sentinel node (SN), being
99mTc‐MIBI positive in 10. No patient with negative SNB developed regional recurrence during the study.
99mTc‐MIBI had a sensitivity of 83% and a specificity of 93%. We conclude that SNB remains the procedure of choice for detecting subclinical lymph node involvement from melanoma.
99mTc‐MIBI could have an alternative role in lymph node staging of patients who are not good candidates of SNB, that needs to be tested in appropriate trials. |
Keywords : lymph node metastases, melanoma, scintigraphy, sentinel node,
99mTc‐MIBI |
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