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Macronodular iatrogenic acne due to amineptine


European Journal of Dermatology. Volume 9, Number 6, 491-2, September 1999, Votre diagnostic !

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Author(s) : Ramon Grimalt, José M. Mascaro-Galy, Juan Ferrando, Mario Lecha

Summary : A 42-year-old Caucasian woman came to our Department because of the rapid onset of multiple nodules on her face. The patient stated that the lesions started one year previously and rapidly grew to their present size. Her past medical history was significant for several episodes of renal calculi, hypertension, type II diabetes mellitus, arthrosis and depression. She was following a medical treatment quite anarchically based on: diclofenac, atenolol, hydrochlorothiazide, melitracen hydrochloride-flupenthixol dihydrochloride (Deanxit®), amineptine, lorazepam, glibenclamide and metformin. Clinical examination revealed the presence of multiple nodular lesions on her face (Fig. 1) that deformed her anatomy in some areas (Fig. 2). A closer examination revealed also the presence of comedones, non-inflammatory papules, cystic lesions and confluent masses.

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