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 Printable version |
Demonstration of HPV 24 in long-standing Heck’s disease with malignant transformation |
European Journal of Dermatology. Volume 9, Number 6, 477-9, September 1999, Cas cliniques
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 Free Article
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Author(s) : B. Niebrügge, E.-M. De Villiers, K.-L. Gerlach, I. Franke, H. Gollnick |
Summary : We report on the rare case of a 64-year-old European woman with a viral acanthoma of the oral mucosa of the clinical Heck type with unprecedented molecular-biological proof of HPV 24 DNA and so far undescribed malignant transformation with a long existence of the vegetation. After surgical therapy a circumscribed relapse of viral acanthoma developed, which responded favourably to a combined antiviral and antiproliferative therapy with acitretin perorally and interferon, first subcutaneously, later intralesionally for 3 months. |
Keywords : acitretin, Heck’s disease, HPV 24, interferon, malignant transformation, viral acanthoma. |
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