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 Printable version |
Sebum rheology evaluated by two methods in vivo. Split-face study of the effect of a cosmetic formulation |
European Journal of Dermatology. Volume 9, Number 6, 455-7, September 1999, Revues
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 Free Article
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Author(s) : C. Piérard-Franchimont, O. Martalo, A. Richard, A. Rougier, G.E. Piérard |
Summary : Modulation of the rheological characteristics of sebum at the surface of the skin might represent a valuable strategy for the treatment of seborrhea. In this field, only a small number of studies have addressed sebum diffusion within the stratum corneum. In an open, split-face study conducted on 20 men, we measured the sebosuppressive effect of Effidrate® cream which is based on a glycerol alkyl-ether. Measurements were made in the morning at three-week intervals for a total period of 3 months. Sebum casual levels and sebum excretion rates were measured using a SM810® Sebumeter. Lipid-absorbent Sebutape® was also used to collect all the sebum released from infundibular reservoirs over a four-hour period. Clinical assessments were relatively uninformative but the photometric measurements showed that Effidrate® cream had a sebosuppressive action. The underlying biological mechanism remains unclear but a hypothesis based on enhanced sebum absorption by the stratum corneum is discussed. |
Keywords : sebum, glycerol alkyl-ether, stratum corneum, follicular reservoir. |
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