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Aggressive angiodestructive variant of primary cutaneous CD30+ lymphoma: how to classify?


European Journal of Dermatology. Volume 7, Number 1, 49-52, January - February 1997, Cas cliniques

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Author(s) : U. Jappe, I. Franke, H. Gollnick

Summary : Clinically, CD30+ lymphoma may present the following three manifestations: the rare primary cutaneous unilocular manifestation with a rather favourable prognosis, the primary cutaneous disseminated form with a poorer prognosis and the primary visceral type characterized by an aggressive course. According to the redefined lymphoma classification of 1994 recently introduced by the European organization of research and treatment of cancer (EORTC), the primary cutaneous CD30+ lymphoma belongs to the group of low-grade lymphomas. In this paper, we present two cases of primary cutaneous, anaplastic large-cell CD30+ lymphomas, one of the B cell type and the other of T cell origin. They are both characterized by an angiodestructive growth and a fulminating clinical course which puts into doubt the classification of this type as belonging to the low-grade or favourable-prognosis lymphomas.

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