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 Printable version |
The safety of calcitriol 3 mug/g ointment. Evaluation of cutaneous contact sensitization, cumulative irritancy, photoallergic contact sensitization and phototoxicity |
European Journal of Dermatology. Volume 11, Number 3, 219-24, May - June 2001, Thérapie
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 Free Article
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Author(s) : C. Queille-Roussel, L. Duteil, A. Parneix-Spake, S. Arsonnaud, E. Rizova |
Summary : Vitamin D analogues are widely used for the treatment of psoriasis. A new topical formulation of calcitriol (3 mug/g ointment*) has been shown to be effective in the treatment of stable plaque-type psoriasis. This paper reports the results of four separate studies designed to evaluate specific local-safety parameters: cumulative irritancy, cutaneous contact sensitization, potential photoallergic contact sensitization and phototoxicity. Calcitriol 3 mug/g ointment was classified as non-irritant when compared to calcipotriol, tacalcitol and white petrolatum. Petrolatum and tacalcitol were slightly irritant and calcipotriol moderately irritant. No sensitization was observed with calcitriol 3 mug/g ointment. With regard to phototoxic potential, sites treated with calcitriol 3 mug/g ointment or vehicle ointment were less irritated than those treated with white petrolatum or those that were untreated. Using standard photoallergenicity testing methodology, there were no skin reactions of a photoallergic nature to the study material. These studies showed that calcitriol 3 mug/g ointment is a well-tolerated treatment for stable plaque-type psoriasis.
* Silkis Ointment, Galderma laboratories. |
Keywords : calcitriol 3 mug/g ointment, irritancy, photoallergic, phototoxicity, sensitization. |
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