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Unilateral anhidrosis First clinical manifestation of bronchial carcinoma


European Journal of Dermatology. Volume 11, Number 3, 257-8, May - June 2001, Votre diagnostic !

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Author(s) : M.A. Muñoz-Pérez, J. Mazuecos, M. Ortega F. Camacho

Summary : A 69-year-old white man presented with a 6 month history of pain and paresthesia on his left shoulder that slowly extended to the left pectoral area, and absence of sweating over the left upper half of his body. He also complained of hyperhidrosis of the right side of the body. Results of sweat testing using one-step iodine-starch method demonstrated left-sided anhidrosis affecting the face, upper limb, and chest (Fig. 1). Results of neurological examination demonstrated no sensory, thermic nor pain deficit. Superficial and deep reflexes were normal. He has no associated ptosis or miosis. Pilocarpina 0.1 mL of 1/1,000 solution was injected subcutaneously on the volar surface of both forearms after iodine and starch powder was applied, and sweat was only noted at the injection site in the right arm, with absence of sweating in the left arm. Examination of a skin biopsy specimen from the left upper back revealed poorly developed eccrine glands. A thoracic X-ray showed a deviation of the trachea (Fig. 2) and a computed axial tomographic (CT) scan also revealed a solid mass next to the apical left and posterior pleura (Fig. 3).

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