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 Printable version |
Efficacy and tolerability of natural synergised pyrethrins in a new thermo labile foam formulation in topical treatment of scabies: a prospective, randomised, investigator-blinded, comparative trial vs. permethrin cream |
European Journal of Dermatology. Volume 13, Number 1, 69-71, January - February 2003, Thérapie
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 Free Article
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Author(s) : PierLuigi AMERIO, Rodolfo CAPIZZI, Massimo MILANI |
Summary : We compared in a prospective, randomised, investigator-blinded trial, the efficacy and tolerability of a new synergised-pyrethrins thermo-labile foam (F) formulation with permethrin 5 % cream (P) in 40 patients with scabies. Clinical evolution of scabetic lesions (Clinical grading = CG) and itching intensity (IS) were assessed, using a 5-point semi-quantitative score, at baseline, at week 2 and 4. F and P were equally effective in the clinical resolution of scabetic lesions. As compared to baseline, P reduced CG and IS from 3.4 ± 0.7 and 3.1 ± 0.4 to 0.2 ± 0.6 and 1.4 ± 1, at week 2, and to 0.0 ± 0.0 and 0.1 ± 0.3 at week 4, respectively (P < 0.001). F reduced CG and IS from 3.3 ± 0.5 and 3.2 ± 0.4 to 0.05 ± 0.2 and 0.4 ± 0.6 (week 2) and to 0.0 ± 0.0 and 0.0 ± 0.0 (week 4), respectively (P < 0.0001). As compared to P group, the IS in F group, at week 2, was significantly lower (0.4 ± 0.6 vs. 1.4 ± 1.1) (P < 0.0013). This foam formulation was at least as effective as permethrin 5 % cream in the treatment of scabies. In comparison with permethrin the foam induced a more rapid and complete resolution of itching. |
Keywords : Scabies, pyrethrins, permethrin, randomised controlled trial, thermolabile foam |
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