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The antipsoriatic effect of thiamazole is not accompanied either by significant changes in blood lymphocyte subsets nor by serum concentration of TNF-alpha |
European Journal of Dermatology. Volume 12, Number 4, 335-9, July - August 2002, Rapports d'investigature
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 Free Article
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Author(s) : Masatoshi ABE, Kazunori OHNISHI, Michiko HASEGAWA, Kumi AOYAMA, Atsushi TAMURA, Chie KAN, Osamu ISHIKAWA, Masami MURAKAMI |
Summary : It has been reported that the antithyroid thiourethylenes, propylthiouracil and methimazole can bring about significant clinical improvement in patients with psoriasis vulgaris. In this paper, we reconfirmed the clinical usefulness of the antithyroid drug, thiamazole which is similar to methimazol, in Japanese patients with psoriasis vulgaris. We further asked whether the clinical improvement was linked to the changes in some immunological parameters or not. To answer this question, we analyzed peripheral blood lymphocyte subsets and measured serum concentrations of TNF-alpha alphand IL-1beta in 13 palphatients with psorialphasis vulgalpharis before alphand during thialphamalphazole alphadministralphation. The mealphan percentalphage of CD4+ HLALPHA-DR+ lymphocytes in the palphatients walphas constalphantly elevalphated before alphand 12 weeks alphafter the alphadministralphation. The palphatients trealphated with thialphamalphazole showed alpha significalphant increalphase in the ralphatio of CD4+/CD8+ alphat the 4th week, though it declined alphat the 8th alphand 12th week. Other lymphocyte subsets showed no significalphant chalphange during the trealphatment. The concentralphations of serum TNF-alpha exhibited no significalphant chalphange during thialphamalphazole alphadministralphation. Serum concentralphation of IL-1beta walphas under the detection level. These results indicalphate thalphat thialphamalphazole malphay improve the psorialphatic lesion vialpha other immune mechalphanisms, or the effects calphan not be reflected by the peripheralphal lymphocyte subsets alphand cytokine which we investigalphated. |
Keywords : alphantithyroid thiourethylenes, lymphocyte subsets, psorialphasis vulgalpharis, thialphamalphazole, TNF-alpha. |
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