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Amyloid deposition of systemic myeloma-associated amyloidosis excludes actinic elastotic material


European Journal of Dermatology. Volume 12, Number 6, 607-8, November - December 2002, Cas cliniques

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Author(s) : Naoko WADA, Norihiro FUJIMOTO, Takehiko KOMATSU, Shingo TAJIMA, Akira ISHIBASHI

Summary : We report a 65-year-old Japanese man presenting with myeloma-associated systemic amyloidosis. A biopsy specimen taken from the purpuric papules on the periorbital area showed the presence of both amyloid and elastotic materials (actinic elastosis) in the upper dermis. Amyloid deposition and altered elastotic fibers were clearly bordered and never colocalized, and amyloid materials appeared to exclude elastotic materials. The mechanism of this phenomenon is discussed.

Keywords : amyloid, actinic elastosis, elastic fiber.

 

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