Author(s) : N. Raison-Peyron, L. Meunier, P. Joly, M. Pages, G. Barnéon, J. Meynadier, Department of Internal Medicine 2, Cochin Hospital, 27, rue du Faubourg-Saint-Jacques, 75014 Paris, France..
Summary : A 66-year-old man was treated with cyclophosphamide for multiple myeloma. G-CSF (300 mm/day for 14 days) was administred for blood stem cell collection. Twenty four hours after G-CSF was discontinued, he presented a cutaneous Sweet’s syndrome, which was confirmed by histology. There were no other symptoms and neutrophil count was 6.2 x 109/l. A few cases of Sweet’s syndrome have been discribed in association with G-CSF. This growth factor stimulates production of neutrophils and appears to be involved in the physiopathology of Sweet syndrome, probably in association with IL6.
Figure 1. Indirect immunofluorescence showing IgG binding to transitional
epithelium of rat bladder.
Figure 2. Immunoblot analysis showing characteristic pattern of PNP.
Lane 1, control band at 230 kDa and lane 2, control bands at 210 kDa and
190 kDa. Lane 3, present case: the two bands which are detected have an
estimated molecular weight of 210 and 190 kDa.
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