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 Printable version |
Cellular allergen stimulation test in the diagnosis of intolerance to non-steroidal antiinflammatory drugs |
European Journal of Dermatology. Volume 7, Number 5, 377-8, July - August 1997, Cas cliniques
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 Free Article
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Author(s) : T.M. Zollner, C. Röder, R.J. Werner, S. Diehl, R. Kaufmann |
Summary : We report a patient with urticaria and rhinoconjunctivitis as the major symptoms of intolerance to nonsteroidal antiinflammatory drugs. The recently developed cellular allergen stimulation test revealed intolerance to diclofenac, ibuprofen and indomethacin indicated by an increased sulfidoleukotriene release by leukocytes in the presence of the above mentioned compounds compared to 10 healthy controls. In contrast, stimulation of leukocytes with acetyl-salicylic acid showed a sulfidoleukotriene release comparable to that of healthy controls. Double blind, placebo controlled provocation tests confirmed the results of the in vitro tests regarding diclofenac, ibuprofen, indomethacin and acetyl-salicylic acid. This case report clearly documents that the determination of sulfidoleukotriene release after stimulation of leukocytes is a major contribution to the diagnosis of intolerance reactions. However, because of the still limited experience this test with substances other than acetyl-salicylic acid, it cannot substitute provocation tests. |
Keywords : cellular allergen stimulation test, intolerance, nonsteroidal antiinflammatory drugs, provocation test, pseudoallergy, urticaria, rhinoconjunctivitis, sulfidoleukotriene. |
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