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 Printable version |
The novel drug CS-891 inhibits 5*-reductase activity in freshly isolated dermal papilla of human hair follicles |
European Journal of Dermatology. Volume 10, Number 8, 593-5, December 2000, Revues
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 Free Article
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Author(s) : S. Niiyama, K. Kojima, T. Hamada, R. Happle, R. Hoffmann |
Summary : The local conversion of testosterone (T) to the more potent androgen dihydrotestosterone (DHT) by 5alpha-reductase (5aR) is implicated in the pathogenesis of androgenetic alopecia (AGA). Recently, the clinical effectiveness of finasteride, a selective type II 5aR inhibitor, in treating AGA has been documented, and these clinical studies have shown that circulating DHT is lowered by 60-70% in men taking finasteride. The source of the residual circulating DHT is presumed to be due to type I 5aR activity which is not affected by finasteride. Several novel compounds with potent dual inhibitory activity on both isoenzymes have been described and CS-891 is one of them. This compound may be likewise effective in the prevention or treatment of AGA. As a prerequisite for such an action CS-891 should be able to inhibit 5aR activity in its target tissue: the hair follicles (HF). Here we report on the capability of CS-891 to inhibit 5aR activity in dermal papillae (DP) of human HF. |
Keywords : androgen, androgenetic alopecia, hair, hair loss. |
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