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Clear cell syringoma |
European Journal of Dermatology. Volume 10, Number 8, 633-4, December 2000, Votre diagnostic !
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 Free Article
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Author(s) : A. Shimizu, Y. Nagai, O. Ishikawa |
Summary : A 40-year-old Philippino woman presented with multiple small papules on both lower eyelids and the upper part of her cheeks. None of her family members had similar lesions. Although she had been treated with insulin for diabetes mellitus since 1994, the control of the disease was poor. The papules appeared in 1997 and have gradually increased in number. Physical examination revealed many flesh-colored or slightly reddish, smooth-surfaced, half-grain sized papules on her lower eyelids and the upper part of her cheeks. Abnormal laboratory data were as follows: triglyceride: 255 mg/dl (35-130 mg/dl); blood sugar: 285 mg/dl (2 hrs after meal); hemoglobin A1c: 10.2% (4-6%). Histopathological examination revealed some cell nests consisting of clear cells in the upper dermis. The cell nests were surrounded by fibrous stroma, and contained amorphous material in the intraductal space. The clear cell had a large vacuolated cytoplasm with a small hyperchromatic nucleus in the pericytoplasm. Periodic acid-Schiff (PAS) staining showed reactive spots in the cytoplasm and the intraductal space. The PAS-positive reaction was diminished after diastase digestion. |
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