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 Printable version |
Anticancer drugs management in renal insufficiency patients |
Bulletin du Cancer. Volume 99, Number 3, 323-31, Mars 2012, Synthèse
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 Résumé
Texte intégral
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Author(s) : Sarah Zimmer-Rapuch, Stéphanie Lheureux, Fabien Brocard, Nicolas Janus, Vincent Launay-Vacher, Isabelle Ray-Coquard |
Summary : Anticancer drug management is complicated especially in renal insufficiency patients, a frequent situation in oncology. Several aspects need to be taken into account: first, the dosage. In this population, the kidney fails to eliminate drugs. Consequently, dosage adjustment can be necessary for drugs with pharmacokinetic profile altered by renal insufficiency in order to avoid dose-related side effects due to accumulation of the drug. Secondly, renal tolerance is an important aspect of anticancer drug management as renal insufficiency is a risk factor for developing renal side effects. Prevention of renal side effects is essential and means to limit this toxicity should be used, especially with hydration. Finally, it is essential to consider all the treatments prescribed in renal insufficiency patients in order to avoid accumulation of nephrotoxic drugs. |
Keywords : renal insufficiency, pharmacokinetics, renal tolerance, dose-related side effects, nephrotoxicity |
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