How to evaluate renal function in cancer patients

Vincent Launay-Vacher; Sarah Zimner-Rapuch; Olivier Moranne

doi:10.1684/bdc.2011.1485



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How to evaluate renal function in cancer patients
Bulletin du Cancer. Volume 99, Number 3, 277-83, Mars 2012, Synthèse
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Author(s) : Vincent Launay-Vacher, Sarah Zimner-Rapuch, Olivier Moranne
Summary : The evaluation of renal function in patients with cancer is necessary. Measuring the actual glomerular filtration rate of the patient is the gold standard. This is usually done using a measure of the renal clearance of a marker of glomerular filtration rate (inulin) or a radio-marker (EDTA Chrome 51, ⁵¹Cr-EDTA). However, these measures are complex and very constraining for the patient and in terms of organization and equipment. It is possible to estimate renal function by calculation. There are in the literature many evaluation formulae available. However, it is essential to use a tool reliable enough to determine an appropriate estimate of renal function, and adjust the doses of treatment if necessary. The choice of the abreviated MDRD (aMDRD) formula is so far the recommended option in oncology.
Keywords : renal function, glomerular filtration rate, Cockroft, MDRD, cancer