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 Printable version |
Focus on granulocyte colony-stimulating factor induced pulmonary toxicity |
Bulletin du Cancer. Volume 99, Number 2, 211-7, Février 2012, Synthèse
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 Résumé
Texte intégral
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Author(s) : Élise Noël-Savina, Renaud Descourt |
Summary : Granulocyte colony-stimulating factor (G-CSF) are frequently used in oncology and haematology practice. Respiratory disturbance has been reported during administration of G-CSF. G-CSF may induce pulmonary toxicity but this fact remains an open debate because of its frequent association with other drugs. The action of these treatments could explain a part of the pulmonary events but not completely. The specific pulmonary effect of the G-CSF is probably underestimated. Most of these pulmonary events occur in association with other risk factors, mainly when a pneumonia occurs during the neutropenia. However, G-CSF are recommended in febrile neutropenia. |
Keywords : granulocyte colony-stimulating factor, ARDS, pneumonia, neutropenia, recovery aplasia, pulmonary toxicity |
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