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 Printable version |
Cell cycle and molecular targets: CDK inhibition |
Bulletin du Cancer. Volume 99, Number 2, 163-71, Février 2012, Synthèse
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 Résumé
Texte intégral
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Author(s) : Philippe Carassou, Laurent Meijer, Sylvestre Le Moulec, Jean Aoun, Leila Bengrine-Lefèvre |
Summary : Protein phosphorylation is a fundamental post-translational modification. It regulates a large number of critical cellular processes (differentiation, division, proliferation, apoptosis). Cell division is a process including a series of phases by which a parent cell divides into two daughter cells. The cells enter these stages then progress within the cell division under an accurate control by many proteins. These proteins are activated by phosphorylation. Cyclin-dependent kinases are responsible for this phosphorylation and therefore represent potential therapeutic targets especially in oncology. |
Keywords : cell cycle, cyclin-dependent kinases, roscovitine, indirubin, meriolin, antitumor activity |
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