|
|
 |
 |
| |
 Printable version |
Therapeutic role of systematic retroperitoneal lymphadenectomy in endometrial cancer |
Bulletin du Cancer. Volume 99, Number 2, 10-7, Février 2012, Electronic journal of oncology
|
 Full Text
|
Author(s) : Hui Zhang, Lin Jia, Qing Zhang, Youzhong Zhang, Xingsheng Yang, Beihua Kong |
Summary :
Objective. The purpose of this study was to evaluate the therapeutic role of systematic retroperitoneal lymphadenectomy in patients with endometrial cancer.
Methods. From December 2003 to December 2008, 349 eligible patients who underwent surgical staging procedures at primary treatment were retrospectively analyzed: systematic lymphadenectomy group (
n \= 246) and no-lymphadenectomy group (
n \= 103). Survival was analyzed using Kaplan-Meier method and Cox proportional hazards model.
Results. Overall, patients who underwent lymphadenectomy improved 5-year disease-free survival (89.0%
versus 80.7%,
P \= 0.019) and overall survival (92.8%
versus 81.5%,
P \= 0.001) compared to those who did not undergo lymphadenectomy. Overall survival was not related to lymphadenectomy in 212 low-risk patients (93.1%
versus 84.6%,
P \= 0.176). However, this association was found in 137 patients with intermediate and high-risk (86.2%
versus 73.3%,
P \= 0.021). Multivariate Cox regression analysis showed that FIGO stage (
P \= 0.037) and lymphadenectomy (
P \= 0.023) were independent prognostic factors for overall survival.
Conclusions. Systematic retroperitoneal lymphadenectomy has a potentially therapeutic role on survival in surgically staged patients with endometrial cancer. |
Keywords : endometrial cancer, lymphadenectomy, prognosis |
|
