Printable version

Bulletin du Cancer. Volume 98, Number 2, 113-9, Février 2011, Article original

Résumé   Article gratuit

Author(s) : Sophie Taïeb, Nathalie Rocourt, Fabrice Narducci, Éric Leblanc, Claude Adenis, Charles Fournier, Philippe Doutrelant, Jean-Philippe Peyrat, Philippe Vennin

Summary : As part of a study in the North of France for screening pelvic tumours with plasma proteomic analysis, we included 82 women with hereditary risk of ovarian cancer. We report here the consequences of organized screening with usual tests. CA 125 sampling and a transvaginal pelvic ultrasound by a radiologist were systematically conducted every 6 months. Seventy-two patients were eventually evaluable. Two incident cases of peritoneal carcinomatosis (FIGO IIIB, malignant epithelial serous high-grade tumors) were discovered in two asymptomatic women with a deleterous BRCA1 mutation (2.7%). We did not observe any other primary cancer cases but an ovarian metastasis of a breast cancer. Forty women went off the study: 32 had a prophylactic bilateral salpingo-oophorectomy. Consistent with the literature, biannual screening tests combining CA125 and pelvis ultrasound is ineffective for early detection of a pelvic tumor of tubal or ovarian origin. Testing for BRCA1 or BRCA2 deleterious mutations is then crucial for suspected family syndromes of breast and ovarian cancer. For women carrying a deleterous mutation on BRCA1/2 a salpingo-oophorectomy is the only way, only the time of this surgery is debatable.

Keywords : early diagnosis of cancer, ovarian neoplasms, CA-125 antigen, ultrasonography, hereditary risk