Printable version

Bulletin du Cancer. Volume 98, Number 2, 19-24, Février 2011, Electronic journal of oncology

Texte intégral

Author(s) : Muhammad Zaeem Noman, Houssem Benlalam, Meriem Hasmim, Salem Chouaib

Summary : The tumor microenvironment is a complex system playing an important role in tumor development and progression. Besides tumor cells, the tumor microenvironment harbours a variety of host-derived cells, such as endothelial cells, fibroblasts, innate and adaptive immune cells, as well as extracellular matrix (ECM) fibers, cytokines, and other mediators. This review discusses the potential role of hypoxia and endothelial cells within tumor microenvironment and emphasizes their interaction with antigen specific killer cells.

Keywords : hypoxia, STAT3, HIF-1α, endothelial cells, tumor cells, CTLs