Implication of HIC1 (Hypermethylated In Cancer 1) in the DNA damage response

Vanessa Dehennaut; Dominique Leprince

doi:10.1684/bdc.2009.0959



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Implication of HIC1 (Hypermethylated In Cancer 1) in the DNA damage response
Bulletin du Cancer. Volume 96, Number 11, 10066-72, novembre 2009, Electronic journal of oncology
Free Article
Author(s) : Vanessa Dehennaut, Dominique Leprince
Summary : HIC1 (Hypermethylated In Cancer 1) is a tumor suppressor gene which is epigenetically inactivated in many human cancers. HIC1 encodes a transcriptional repressor comprising an N-terminal BTB/POZ domain and a C-terminal DNA binding domain containing five Krüppel-like C ₂H ₂ zinc fingers. To date, few HIC1 target genes are known and the regulation of HIC1 activity is not fully deciphered. However, a growing list of studies, summarized in this review, strongly suggest that HIC1 plays a central role in the DNA damage response through the establishment of several complex regulatory loops involving HIC1, p53, SIRT1 and E2F1.
Keywords : HIC1, p53, SIRT1, E2F1, DNA damage