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 Printable version |
Chemoprevention in head and neck cancer and lung cancer |
Bulletin du Cancer. Volume 96, 25-34, Avancées des thérapeutiques ciblées dans les cancers ORL et thoraciques, Revue
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 Résumé
Article gratuit
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Author(s) : J Fayette, L Kiakouama |
Summary : Because of their raised prevalence and mortality, association of secondary tumors and inefficiency of therapeutic conventional (surgery, radio- and chemotherapy), head and neck and lung cancers represent true public health problems. The knowledge of the process of carcinogenesis allowed development of approaches of chemoprevention. The vitamin A and its derivatives showed initially a certain efficacy, but an important toxicity and large trials remained negative. For lung cancers, in the event of continuation of the tobacco, β-carotene and the vitamin A seem even deleterious. Progress in the biology of cancer should allow innovating new approaches of chemoprevention. Today the most effective strategy stays the stop of the tobacco. |
Keywords : chemoprevention, head and neck cancers, lung cancers, surrogate markers, retinoid, β-carotene, EGFR |
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