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 Printable version |
Role of [
18F]-FDG PET-CT in the management of the head and neck cancers |
Bulletin du Cancer. Volume 93, Number 10, 1017-25, Octobre 2006, Article original
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 Résumé
Article gratuit
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Author(s) : Nicolas Fakhry, Marie Barberet, David Lussato, Serge Cammilleri, Olivier Mundler, Antoine Giovanni, Michel Zanaret |
Summary : Objectives : To evaluate the impact of [
18F]-FDG PET/CT image fusion in the management of carcinomas of the upper aero-digestive tract. Methods : This retrospective study included 169 patients with squamous cell cacinoma of the upper aerodigestive tract who underwent a PET/CT for : initial staging (n \= 47), cervical lymphadenopathy from an unknown primary (n \= 22), post treatment surveillance (n \= 68) and detection of recurrent cancer (n \= 32). Results of PET/CT were compared with those of standard workup (CT scan of head, neck and chest and abdominal ultrasound). Histology and clinical follow-up were used as gold-standard. Results : PET/CT was more accurate than standard workup for 6.4 % of patients for the initial staging, 18,2 % of patients for cervical lymphadenopathy from an unknown primary, 20,6 % of patients for post-treatment surveillance and 25 % of patients for detection of cancer recurrence. In all patients, 17,9 % of FDG uptake foci found by PET/CT were false-positives. Conclusion : PET/CT is a reliable tool for the management of carcinomas of the upper aerodigestive tract. The high rate of false-positive findings represents the main limitation of this exam. |
Keywords : FDG-PET, cancer, head and neck, upper aero-digestive tract |
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