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 Printable version |
PI3K and RAC signalling in leukocyte and cancer cell migration |
Bulletin du Cancer. Volume 93, Number 5, 10044-52, Mai 2006, Electronic Journal of Oncology
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 Free Article
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Author(s) : Mark A Barber, Heidi CE Welch |
Summary : Leukocytes and amoeboid-stage cancer cells migrate in a similar manner. Key signalling molecules regulating leukocyte and cancer cell migration are phosphoinositide 3-kinase (PI3K) and the Rho family of small GTPases. While PI3K activity defines the leading edge of the cell, Rho family GTPases regulate the cytoskeletal remodelling during polarisation and migration. We review here briefly the roles of PI3K, of the Rho-family GTPase Rac, and of the guanine-nucleotide exchange factors that activate Rac, in leukocyte and cancer cell migration. |
Keywords : PI3K, PI3 kinase, Rac, leukocyte, migration, cancer |
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