Expression of PTEN, cyclin D1, P27/KIP1 in invasive ductal carcinomas of the breast and correlation with clinicopathological parameters

Hüseyin Engin; Esmen Baltali; Nilüfer Güler; Gülnur Güler; Gülten Tekuzman; Aysegül Üner



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Expression of PTEN, cyclin D1, P27/KIP1 in invasive ductal carcinomas of the breast and correlation with clinicopathological parameters
Bulletin du Cancer. Volume 93, Number 2, 10021-6, Février 2006, Electronic journal of oncology
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Author(s) : Hüseyin Engin, Esmen Baltali, Nilüfer Güler, Gülnur Güler, Gülten Tekuzman, Aysegül Üner
Summary : In this study, tumour tissue samples of 85 primary breast cancer patients were evaluated for phosphatase and tensin homolog deleted on chromosome ten (PTEN), cyclin D1 and P27/Kip1 expression patterns. The results were correlated with clinicopathological parameters. Loss of PTEN protein expression was present in 32.5% of the cases. Cyclin D1 was overexpressed in 54.2% and P27/Kip1 in 89.3% of the cases. Statistically significant associations were found between PTEN and cyclin D1 expression patterns, and cyclin D1 expression and tumour size.
Keywords : breast, PTEN, cyclin D1, P27/Kip1