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 Printable version |
Desmopressin and other synthetic vasopressin analogues in cancer treatment |
Bulletin du Cancer. Volume 93, Number 2, 10007-12, Février 2006, Electronic journal of oncology
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 Free Article
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Author(s) : Daniel E Gomez, Giselle V Ripoll, Santiago Girón, Daniel F Alonso |
Summary : Desmopressin (DDAVP) is a well tolerated and convenient haemostatic agent that can be used in a number of clinical conditions with bleeding diathesis. It has several effects on the haemostatic system, causing endogenous release of coagulation factor VIII, von Willebrand factor and tissue-type plasminogen activator, among others. In this review we present a growing body of evidence showing that DDAVP treatment may impair spread of cancer cells and contribute to encapsulation of tumour tissue. Our data in preclinical animal models suggest a potential application of DDAVP in the perioperative management of aggressive solid tumours. Novel vasopressin analogues with improved antitumor effects are currently in development. |
Keywords : desmopressin, metastasis, cancer surgery |
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